Endocrine Abstracts

Background: Hemangiomas of the thyroid gland are extremely rare.Case presentation: We report a case of a 78-year-old euthyroid male patient with a primary cavernous hemangioma of the thyroid gland. The patient presented for evaluation of a symptomatic, slowly growing neck mass. He did not have any previous medical history and, moreover, had no history of trauma, FNA or other neck procedures. Ultrasound scan revealed a multinodular goiter and a hypoechoic...

Objective: The Swiss Primary HyperParaThyroidism (PHPT) Cohort Study is an ongoing, prospective, non-interventional project collecting clinical, densitometric, biochemical and outcome data in patients with PHPT. The aims are to describe the profile of these patients particularly neurobehavioral and cognitive symptoms, changes in calcium and PTH over time and treatment modalities.Methods: Patients newly diagnosed with PHPT and with high serum calcium leve...

Background: Diabetic gastroparesis is a disabling condition with no consistently effective treatment. Ghrelin infusion, in animal studies, increases gastric emptying and reverses post-operative ileus. We present the results of the first double-blind placebo-controlled cross-over study of ghrelin in gastric emptying in patients with diabetic gastroparesis....

BackgroundDiabetic gastroparesis is a disabling condition with no consistently effective treatment. Ghrelin infusion, in animal studies, increases gastric emptying and reverses post-operative ileus. We present the results of the first double-blind placebo-controlled cross-over study of ghrelin in gastric emptying in patients with diabetic gastroparesis.MethodsTen insulin requiring diabetic patients (5 men, 6 ...

The thyrotroph tumors or pituitary neuroendocrine tumors (PitNET) classify as tumors of Pit-1 family. These tumors are rare and may be monohormonal, secreting only TSH, or plurihormonal, secreting TSH-GH±PRL, with or without acromegaly. The objectives of this retrospective study were to confirm the frequency of the plurihormonal subtype and to compare the clinical, biological and pathological characteristics of these two pathological subtypes. We retrospectively studied t...

Background: While gonadotroph tumors are lacking both medical treatment options and prognostic markers, the tumor microenvironment represents a promising tool. The aim of this study was to 1) identify new tumor microenvironment actors in gonadotroph tumors, 2) gain insight into the tumorigenesis mechanisms driven by these tumor microenvironment cells, and 3) identify new tumor microenvironment-related prognostic markers, as well as new therapeutic targets.<p class="abstext...

Objective: To evaluate the association between genetic background and the presence of oligo- or amenorrhea in a sample of adolescent girls diagnosed with anorexia nervosa compared with controls.Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calculated body mass index (BMI) z-scores adjusted for age, as wel...

Context: Anti-programmed cell death-1 (Anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations. Acquired generalized lipodystrophy (AGL), is a rare disease, thought to be immune-mediated, characterized by loss of adipose tissue and insulin resistance-associated complications. We describe the first case of AGL induced by immune checkpoint therapy.<p class="ab...

Introduction: Single nucleotide polymorphic variants of the methylenetetrahydrofolate reductase (MTHFR) gene have been related with a tendency to gain weight according to recent studies. The aetiology of atypical anorexia nervosa remains under investigation and might be associated with the genetic background. The aim of this study was to evaluate the association between the presence of A1298C or C677T polymorphisms of the MTHFR gene and weight status in a sample of adolescent ...

Context: Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations.Aims: To study the correlation between characteristics of corticotropinomasand SST5 expression/USP8 mutation status; to describe the response to pasireotide in 5 patients.Design: Retrospective cohort study.Metho...